Characterization of skeletal phenotypes of TRα1PV and TRβPV mutant mice: implications for tissue thyroid status and T3 target gene expression

نویسندگان

  • Patrick J. O'Shea
  • J.H. Duncan Bassett
  • Sheue-yann Cheng
  • Graham R. Williams
چکیده

Bone development is extremely sensitive to alterations in thyroid status. Recently, we analyzed the skeletal phenotypes of mice with the dominant negative resistance to thyroid hormone (RTH) mutation PV targeted to either the thyroid hormone receptor (TR) alpha1 or beta gene. This perspective summarizes our findings to date and explores the wider implications for thyroid status and T3 target gene expression in individual tissues.

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عنوان ژورنال:
  • Nuclear Receptor Signaling

دوره 4  شماره 

صفحات  -

تاریخ انتشار 2006